Amends the Illinois Vehicle Code. Defines "autonomous vehicle" as a motor vehicle that is equipped with hardware and software that are collectively capable of performing the entire dynamic driving task on a sustained basis within the operational design domain, if any, including achieving a minimal risk condition, without any expected intervention or supervision by a conventional human driver, where applicable. Provides that an autonomous vehicle registered in this State shall continue to meet federal standards and regulations for a motor vehicle. Provides that an operator of an autonomous vehicle shall not use the vehicle to engage in the transport of interstate commerce or the transporting of passengers, or the transporting of goods, unless a human safety operator is physically present in the autonomous vehicle such that he or she has the ability to monitor the vehicle's performance and intervene if necessary, including operating or shutting off the vehicle. Provides that a human safety operator must continue to meet all federal and State qualifications for autonomous and nonautonomous vehicles.