Amends the Medical Assistance Article of the Illinois Public Aid Code. Requires the Department of Healthcare and Family Services to ensure that patients experiencing opioid-related overdose or withdrawal are admitted on inpatient status, rather than observation status, for at least 48 hours from the time of admittance to a safety-net hospital. Prohibits managed care organizations from denying inpatient coverage to safety-net hospitals for patients presenting with opioid overdose or withdrawal diagnosis for at least 48 hours from the time of admittance.